This article by Gaurav Dubey was originally published on Microdose Psychedelic Insights and appears here with permission.
The revival of psychedelic science and research has produced a fascinating wealth of information about their therapeutic potential. From treatment resistant depression to PTSD and addiction, psychedelic medicine is proving to be a powerful tool for healing the human race. One of the most surprising discoveries is the incredibly powerful psychedelic known as 5-MeO-DMT.
Produced naturally in some plants, and most notably, in the venom of the Sonoran desert toad, Bufo Alvarius, 5-MeO-DMT was discovered only 30 some years ago. Since that time, it has been reported to produce one of the most powerful and profound psychedelic experiences known to man. This guide will explore the mystical 5-MeO-DMT experience, it’s potential therapeutic applications and spotlight advanced 5-MeO-DMT practitioner Joël Brierre of Kaivalya Kollectiv, who I had the pleasure of partaking in the 5-MeO-DMT experience with.
What is 5-MeO-DMT?
5-MeO-DMT is a powerful psychedelic in the tryptamine class of compounds found in many plant species and at least one toad species. Seeds containing 5-MeO-DMT and bufotenin have been used in South American entheogenic rituals in a snuff preparation known as yopo. However, recent studies have shown the bufotenin is largely responsible for the hallucinogenic effects of yopo due to the extremely limited amount of 5-MeO-DMT.
It was only recently that significant quantities of 5-MeO-DMT was discovered in the secretions of the Sonoran desert toad. A fascinating account of this discovery can be found in this episode of Hamilton’s Pharmacopeia.
Fan of Hamilton Morris? He was in attendance at our first Molecular Masterclass virtual event spotlighting ketamine therapeutics. Check out his presentation in our video recording of the event here!
What Does the Research Say About 5-MeO-DMT?
The state of clinical research around this compound is still very limited. However, early results do show great promise. In fact, a recent study found that:
“A single inhalation of the psychedelic drug 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is associated with sustained improvements in satisfaction with life, mindfulness, and a reduction of psychopathological symptoms, according to preliminary research published in Psychopharmacology.”
It is also important to note that such a powerful mystical experience is paired with a period of significant neuroplasticity and neuronal growth. Another study found that:
“A Single Dose of 5-MeO-DMT Stimulates Cell Proliferation, Neuronal Survivability, Morphological and Functional Changes in Adult Mice Ventral Dentate Gyrus”
Essentially, a single dose of this powerful psychedelic stimulated cell growth, survivability, and changes to the shape and function of brain cells in adult mice. Thus, the importance of an important integration program and conscious activities immediately before and after working with the medicine is particularly important.
Comparing and Contrasting DMT and 5-MeO-DMT
While the name may imply this newly discovered compound is similar to the classic psychedelic DMT, or dimethyltryptamine, the 5-MeO-DMT experience is robustly different and distinctly unique. Both DMT and 5-MeO-DMT have an incredibly rapid onset, are fast acting and have a short duration, sometimes lasting only seven minutes. However, this is where the similarities end.
While the DMT experience is highly visual, full of colorful fractals and sacred geometries, your thoughts still remain coherent. On the other hand, the 5-MeO-DMT experience shatters all senses of self, any concept of “I” that may exist and fully merges your being with the universe …